What is Solid Phase Synthesis Peptide?

Polypeptide synthesis on a solid support, a concept of originality pioneered by Robert Bruce M errifield in 1963, is a major breakthrough in peptide chemistry. 

In solid phase synthesis, it is conventional to assemble peptide chains starting from the C-terminus. 

• First, a linker is introduced on the polymer carrier; then, the N-terminal protected amino acid reacts with the functional group of the linker;

• then the temporary protecting group is removed and condensed with the next amino acid, and this step is repeated until synthesis is required The sequence;

• finally, cleaves the covalent bond between the tether and the peptide chain, and removes the insoluble carrier from the dissolved product.