Antibiotice purification; Peptide antibiotic synthesis; Enzyme-catalyzed reaction; Chromatographic separation
Modern biopharmaceutical technologies typically use biological microbial fermentation processes, enzyme-catalyzed reactions, or biologically metabolites obtained by cell culture. Biosynthesis technology can produce many active substances, such as antibodies, antibiotics, etc., but the concentration of biologically active substances is very low, and some is easy to be inactivate, the content of impurities is very high, and many impurities and targets have similar physical and chemical properties, which result Separation and purification difficult.
Sunresin's large pharmaceutical research and development department has proposed different solutions to various problems arising in the biopharmaceutical process through an in-depth understanding of the upstream and downstream industries of biopharmaceuticals. So far, many of our products have been successfully used in the Chinese market.
Our Technique for Bio-pharmaceutical & Life Science
Upstream and downstream multi-point solutions for the biopharmaceutical industry
High-standard resin production line special for the pharmaceutical industry
Peptide antibiotic synthesis--solid phase peptide synthesis
The initial peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa.
Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex Peptide.
Enzyme-catalyzed reaction--immobilized enzyme carrier
The enzyme immobilization technique is to immobilize the free enzyme on a solid support by physical or chemical means, and it needs to keep the same activity as the free enzyme.
Bio-pharmaceuticals separation--Ion exchange and adsorption Resin & system
Ion exchange and adsorption method is a cost-efficient separation technique that has been widely used in the pharmaceutical industry. It is primarily a way to achieve separation and purification on a large scale with ion exchange systems with complex and designable ion exchange resins. It removes impurities, concentrates the target, and produces highly pure pharmaceuticals.
Chromatographic separation--chromatography media
Separation of pharmaceuticals is often a very complex process, especially for substances with similar structures, such as isomers. At this time, it is necessary to perform high-purity pharmaceutical by means of chromatography separation.
Sunresin Techniques used in Bio-pharmaceutical Industry