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SOLID PHASE PEPTIDE SYNTHESIS(SPPS)
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About Solid Phase Peptide Synthesis

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Solid Phase Peptide Synthesis

Peptide Synthesis Resins

Since Solid Phase Peptide Synthesis was first proposed by Robert Bruce Merrifield, the method of synthetic peptides became more popular than liquid phase peptide synthesis because of high efficiency. This method could assemble a peptide chain rapidly through successive reactions of amino acid derivatives on an insoluble support.
The original peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa. Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex. Peptide. The solid phase method is divided into a Boc method and an Fmoc method. It requires the solid phase synthesis of the carrier to achieve the growth of the peptide chain by means of stepwise amino acid condensation. The advantages of solid phase synthesis are ease of purification, shortening of the synthesis cycle, and ease of automation.

Solid phase peptide synthesis(SPPS) support consists of small, polymeric resin beads functionalized with reactive group such as amine or hydroxyl groups, which link to systhesis peptide chain step by step.

Solid phase peptide synthesis(SPPS) resins is insoluble in all common solvents but swells well in most organic solvents. Better swelling degree is benefit for the reaction yields, but for short peptide easy to synthesis, lower swelling degree will be suitable and it will be good at saving solvent.

Solid phase peptide synthesis Resins are rich in variety, complete in specifications and stable in performance.

Typical Applications

  • Solid phase synthesis of Bivalirudin
  • Solid phase synthesis of Eptifibatide
  • Solid phase synthesis of Exenatide
  • Solid phase synthesis of Liraglutide
  • Solid phase synthesis of thymopentin
  • Solid phase synthesis of Thymalfasin
  • Solid phase synthesis of Buserelin
  • Solid phase synthesis of Goserelin
  • Solid phase synthesis of Octreotide
  • Solid phase synthesis of Calcitonin

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We also have good experiences in research and develop the amine acid pre-loading peptide resins, and we have extended resin backbone to hydrophilic matrix, such as DEG series, TEG series, PEG series. Welcome to ask for Sunresin!

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11 2021-06
Online and offline, Sunresin participated at the Aquatech China 2021

As a leading technical solution provider in adsorption and separation technology, Sunresin participated at the Aquatech China trade show with a team of over 20 people from different business units showcasing its latest products, equipment and solutions, especially in the areas of Ultra Pure Water, condensate polishing, drinking water purification, as well as its Remote Solution Operation and Monitoring Center (RESOM).

27 2021-04
Sunresin Time at the IE Expo China 2021

As a leading technical solution provider in the resin adsorption and separation industry, Sunresin participated at the IE Expo with a team of over 20 people from different business units showcasing its latest adsorption products and equipment, as well as overall turn-key solutions in dealing with wastewater and waste gas treatment.

18 2021-03
Enmore Bio Conference (EBC) 2021 kicked off on March 12 in Suzhou

Sunresin, as a listed company specializing in the development of high-performance separation and purification materials, design and manufacturing of high-efficiency separation and purification system devices as well as overall turnkey solutions, participated in the Enmore Bio Conference (EBC) 2021 with a professional team covering marketing, R&D and industrial application, to bring high-quality chromatographic purification media and microcarrier products to provide users in the field of biomedicine with more on-site technical expertise and product support to empower the development of the biomedical industry and provide users with more choices.

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