In the field of synthetic biology, chromatography separation technology is commonly used for the purification and production of synthetic products, as well as for isolating metabolites and identifying the structure and characteristics of compounds and biomolecules. It is also widely applied in the field of adsorption and separation.

The adsorption and separation technology that Sunresin is engaged in is a highly efficient separation and purification platform technology with strong environmental friendliness, high automation, and good operational accuracy. As a leading global company in the adsorption and separation technology industry, we have been actively considering how to integrate our more than 20 years of research and development accumulation and technological advantages in the field of adsorption and separation with the national carbon neutrality path to contribute to the achievement of the dual-carbon goals and help optimize and upgrade downstream application processes.

Sunresin has developed Uniform Particle Ion Exchange Resin using targeted research and development, advanced chromatographic equipment, and strict quality control, utilizing new synthetic biology technology. This resin is designed to address the impurities and high salt content of existing fermentation processes used to produce ergothioneine. It is used for chromatographic desalination, decolorization, and purification, achieving an inorganic/organic salt removal rate of over 95% in high salt systems, reducing conductivity to below 50μs/cm.

To meet the high requirements of enterprises for fluoride content in wastewater and residents' demand for fluoride-free drinking water, Sunresin's research team has continuously researched, developed, and improved targeted adsorption fluoride removal resins LSC-760 and LSC-860 based on the typical industry wastewater quality and treatment process characteristics. Both resins have high selectivity for fluoride in water, with LSC-760 being an activated alumina modified resin and LSC-860 being an activated zirconium modified resin. Currently, these two resins have been applied in the treatment of fluoride-containing wastewater in multiple fields, providing customers with high-quality and efficient fluoride removal solutions. These resins not only effectively reduce fluoride emissions but also reduce environmental pollution and human health hazards, with important environmental and social significance.

In response to the high osmotic pressure of sugar alcohol products on resins, Sunresin Technology has developed SEPLITE® Monojet™ LSF974 and SEPLITE® Monojet™ LSF9730 jetted uniform particle ion exchange resins, which are characterized by uniform particle size, good strength, and long service life. Additionally, the uniform particle size reduces the pressure drop in the resin bed, resulting in a higher online liquid processing capacity compared to conventional resins such as SEPLITE® LSF970 and SEPLITE® LSF973. The resin also has a lower breakage rate and a better impurity removal effect, which can significantly improve production efficiency and reduce production costs.

The new Sunresin Seplife®Oligo dT affinity resin is designed for the purification and isolation of mRNA from in vitro transcription (IVT) manufacturing processes. Using the 20 years experience of Sunresin in manufacturing specialty resins, we have designed a unique technology that manufactures a 50 micron polymeric resin with very uniform particle sizes by seed swelling. The resin is a crosslinked polystyrene divinylbenzene resin functionalized with oligo dT20. The resin effectively captures mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.

The Seplife® dextran ion exchange chromatography resins use the dextran matrix of G series gel filtration chromatography resins (Seplife G-25 and Seplife G-50), and the ion exchange functional ligands of different properties are firmly bonded to the cross-linked dextran matrix. Dextran ion exchange resins are usually stored in the form of dry powder, which must be swollen before use. It is widely used in low molecular weight proteins such as prothrombin and low molecular weight heparin.

Ion exchange chromatography is a column chromatography method that uses the difference in electrostatic force between the exchangeable ions on the ion exchanger and the various ions separated in the surrounding medium, and achieves the purpose of separation through exchange equilibrium. Ion-exchange chromatography has the advantages of high sensitivity, repeatability, good selectivity, and fast analysis speed, and is currently one of the most commonly used chromatography methods.