Sunresin Advances Global Peptide and Oligonucleotide Innovation with Breakthrough Solid-Phase Synthesis Carriers
As the biopharmaceutical industry accelerates into a new era, peptide and oligonucleotide therapeutics have emerged as two of the most dynamic and strategically important drug modalities. Blockbuster drugs such as semaglutide and tirzepatide are reshaping metabolic disease treatment, while Spinraza and Inclisiran have demonstrated the transformative potential of nucleic acid medicines. Behind these innovations lies one essential foundation: solid-phase synthesis technology, and more specifically, the solid-phase synthesis carriers that determine the efficiency, purity, and scalability of peptide and oligonucleotide production.
As the national champion in adsorption and separation materials and a global leader in functional polymer technologies, Sunresin has built a comprehensive and competitive portfolio of peptide and oligonucleotide solid-phase synthesis resins. Through continuous innovation, advanced manufacturing capabilities, and deep collaboration with world-class pharmaceutical partners, Sunresin is becoming a cornerstone supplier in the global biopharmaceutical value chain.
Building Core Competitiveness in Peptide Solid-Phase Synthesis Resins
After years of dedicated development, Sunresin has established a full product matrix covering Wang, 2-CTC, Sieber, Rink and other mainstream peptide synthesis carriers. This portfolio now supports customers across discovery, process development, and commercial manufacturing.
Key technology advantages include:
1. Continuous Product Innovation
Sunresin’s R&D teams focus on the dual goals of high performance and green manufacturing, advancing new carrier technologies such as:
- Low-swelling resins enabling reduced solvent usage
- PS-PEG resins compatible with environmentally preferred solvents
- Low-impurity preloaded amino acid resins
These innovations align with global trends toward greener peptide synthesis.
2. Large-Scale, Reliable Manufacturing
With an annual production capacity exceeding 120 tons and stable ton-scale inventory, Sunresin ensures consistent supply for both R&D and industrial production. All products are manufactured under a strict ISO 9001:2015 quality system, ensuring batch-to-batch reproducibility that meets the stringent requirements of pharmaceutical customers.
3. Exceptional Customization Capabilities
Sunresin provides tailor-made solutions such as customized substitution levels, functional groups, loading capacities, and pre-loaded amino acid carriers. This flexibility enables seamless integration into complex peptide synthesis processes, including those used in GLP-1 class drugs, where Sunresin has become a trusted material supplier through leading CDMO partners.
Strengthening Leadership in Oligonucleotide Synthesis Carriers
As oligonucleotide therapeutics rapidly expand into areas such as RNAi, antisense therapy, and mRNA technology, Sunresin has taken a forward-looking approach to developing next-generation solid-phase carriers for oligonucleotide synthesis.
Technical highlights include:
1. Innovative Structural Design
Based on polystyrene frameworks, Sunresin has engineered large-pore carriers tailored for sterically demanding structures such as GalNAc-conjugated oligonucleotides, significantly improving reaction accessibility and coupling efficiency.
2. Full-Spectrum Application Coverage
Sunresin’s carriers support the synthesis of:
- RNA
- DNA
- Modified oligonucleotides
The company also supplies Unylinker pre-loaded carriers, linker customization, and base pre-loading services to meet diverse registration and process development requirements.
3. Proprietary Technology and Integrated Solutions
With a strong intellectual property portfolio—including 69 Chinese patents, 51 invention patents, and 27 international patents—Sunresin provides robust technical support for customers. Complementary purification media further enable an integrated “synthesis + purification” solution for nucleic acid therapeutics.
Elevating Global Collaboration Through International Technical Exchange
In alignment with its role as a driver of global innovation, Sunresin recently hosted the International Symposium on Peptide and Oligonucleotide Technologies: Innovation and Application Frontiers, held at Sunresin’s headquarters in Xi’an. The event brought together over 200 industry experts, including renowned scientists such as:
Prof. Fernando Albericio, Dr. Alessandra Basso, and Dr. Xianbin Su, along with leading pharmaceutical companies, CDMOs, and academic institutions.
The symposium featured in-depth discussions on:
- Advances in peptide and oligonucleotide solid-phase synthesis carriers
- Process optimization and scalable manufacturing
- Trends in sustainable and green chemistry
- Opportunities for global collaboration and technology integration
By hosting this high-level international exchange, Sunresin showcased its technical leadership, strengthened partnerships with global innovators, and reinforced China’s role in shaping the future of biopharmaceutical materials.
Empowering the Future of Biopharmaceutical Materials
From pioneering high-performance synthesis carriers to building a full innovation ecosystem spanning R&D, manufacturing, and technical exchange, Sunresin continues to push the boundaries of what is possible in functional polymer materials for life sciences.
With deep expertise, world-class quality, and a commitment to sustainable innovation, Sunresin is proud to support the acceleration of peptide and oligonucleotide therapeutics worldwide—helping bring next-generation medicines to patients faster and more reliably.
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