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Seplife® LPF851

Porous, powder, weakly acidic, H+ form, stabilization of Vitamin B12

Description


Seplife® LPF 851 is a low-crosslinking, porous, weakly acidic, cation exchange resin, copolymerized with methacrylic acid-divinylbenzene.
It is an insoluble and supplied as a dry, fine powder, which is suitable for use in pharmaceutical applications, primarily as a carrier for certain basic (cationic) drugs and related substances as a sustained release drug. It is also used to mask objectionable tastes associated with certain basic drugs. Commercial examples of its use include:

  • Stabilization of Vitamin B12

  • Sustained Release of Nicotine

Typical Properties:

Matrix Structure Divinylbenzene-methacrylic acid
Ionic form H+
Physical Appearance White to off white fine powder free of foreign matter and any    agglomeration
Particle size
%>150μm ≦1
%> 75μm 18-30
%< 50μm ≦70
Mass exchange capacity (mmol/g, on dried basis) ≧10
Water content % <10
Water extractable impurities % ≦2
pH 6-9.5
Inorganic ion content
Sodium content (%, on dried basis) ≦0.2
Heavy metals content (%) ≦0.001
Iron ion content (%) ≦0.01
Organic content
methacrylic acid content(ppm) ≦300
Divinylbenzene content (ppm) ≦1.0
Naphthalene content (ppm) ≦20
Unknown single impurity (ppm) ≦1.0
Total unknown impurity (ppm) ≦3.0
Microbial purity
Total bacterial count (cfu/g) ≦100
Total mold count (cfu/g) ≦100


Identification:

Seplife® LPF851

Package and Storage:
Resins should be stored in sealed 25 kg cardboard drum in room temperature and dry place, without exposure to direct sunlight.
The quality guarantee period is normally 1 year.

Cautions:
Material Safety Data Sheet (MSDS) are available for all Sunresin Products. These sheets contain pertinent information that you may need to protect your employees and customers against any known health or safety hazards associated with our products.
SEPLIFE® use acidic solution for regeneration which are corrosive and should be handled to prevent eye and skin contact. The residue organic solvents should be controlled according to safety regulation.
Nitric acid and other strong oxidizing agents can cause explosive reactions when mixed with ion exchange resins. Proper design of process equipment to prevent rapid buildup of pressure is necessary if use that.
Ion exchange resins and adsorbents as produced, contain by products resulting from the manufacturing process. The user must determine the extent to which organic by-products must be removed for any particular use ad establish techniques to assure that the appropriate level of purity is achieved for that use. The user must ensure compliance with all prudent safety standard and regulatory requirements governing the application.

SUNRESIN®and SEPLIFE®are registered trademarks of Sunresin New Materials Co. Ltd., Xi'an

For more information about SEPLIFE®resins, please contact SUNRESIN® directly.

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