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SOLID PHASE PEPTIDE SYNTHESIS(SPPS)
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About Solid Phase Peptide Synthesis

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Solid Phase Peptide Synthesis

Peptide Synthesis Resins

Since Solid Phase Peptide Synthesis was first proposed by Robert Bruce Merrifield, the method of synthetic peptides became more popular than liquid phase peptide synthesis because of high efficiency. This method could assemble a peptide chain rapidly through successive reactions of amino acid derivatives on an insoluble support.
The original peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa. Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex. Peptide. The solid phase method is divided into a Boc method and an Fmoc method. It requires the solid phase synthesis of the carrier to achieve the growth of the peptide chain by means of stepwise amino acid condensation. The advantages of solid phase synthesis are ease of purification, shortening of the synthesis cycle, and ease of automation.

Solid phase peptide synthesis(SPPS) support consists of small, polymeric resin beads functionalized with reactive group such as amine or hydroxyl groups, which link to systhesis peptide chain step by step.

Solid phase peptide synthesis(SPPS) resins is insoluble in all common solvents but swells well in most organic solvents. Better swelling degree is benefit for the reaction yields, but for short peptide easy to synthesis, lower swelling degree will be suitable and it will be good at saving solvent.

Solid phase peptide synthesis Resins are rich in variety, complete in specifications and stable in performance.

Typical Applications

  • Solid phase synthesis of Bivalirudin
  • Solid phase synthesis of Eptifibatide
  • Solid phase synthesis of Exenatide
  • Solid phase synthesis of Liraglutide
  • Solid phase synthesis of thymopentin
  • Solid phase synthesis of Thymalfasin
  • Solid phase synthesis of Buserelin
  • Solid phase synthesis of Goserelin
  • Solid phase synthesis of Octreotide
  • Solid phase synthesis of Calcitonin

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We also have good experiences in research and develop the amine acid pre-loading peptide resins, and we have extended resin backbone to hydrophilic matrix, such as DEG series, TEG series, PEG series. Welcome to ask for Sunresin!

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Latest News

01 2020-12
A Better Choice for Tungsten and Molybdenum Separation

Sunresin has set up special topics and established a special research team based on customers’ needs to conduct research and analysis on the element composition and existing technology of tungsten leaching solution, and successfully developed sepcial resin Seplite® LSC680 for tungsten and molybdenum separation as well as the matching process.

27 2020-11
Acetone Purification and Cycling (Methylamine removal), solvent in the production of PPS (polyphenylene sulfide)

The ion exchange resin (IER) method is very excellent and efficient for acetone purification. Acetone will pass cation exchange resins first and then the anion exchange resins, more than 95% methylamine will be removed.

24 2020-11
Sunresin awarded as Asia's Best Under A Billion by Forbes 

On November 23, 2020,Forbes announced Asia’s Best Under A Billion 2019 list. Sunresin was honored to be selected. The promulgation ceremony originally scheduled to be held in Bangkok, Thailand, was carried out online due to continuous spreading pandemic.

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