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SOLID PHASE PEPTIDE SYNTHESIS(SPPS)
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Solid Phase Peptide Synthesis

Peptide Synthesis Resins

Since Solid Phase Peptide Synthesis was first proposed by Robert Bruce Merrifield, the method of synthetic peptides became more popular than liquid phase peptide synthesis because of high efficiency. This method could assemble a peptide chain rapidly through successive reactions of amino acid derivatives on an insoluble support.
The original peptide antibiotics are also biosynthesized and extracted from the culture of polymyxa or aeruginosa. Another synthetic method of peptides is chemical synthesis, which is divided into liquid phase chemical synthesis and solid phase chemical synthesis. The liquid phase method is mainly used for the synthesis of short peptides. The solid phase synthesis method can be used to prepare long-chain peptides, cyclic peptides, and complex. Peptide. The solid phase method is divided into a Boc method and an Fmoc method. It requires the solid phase synthesis of the carrier to achieve the growth of the peptide chain by means of stepwise amino acid condensation. The advantages of solid phase synthesis are ease of purification, shortening of the synthesis cycle, and ease of automation.

Solid phase peptide synthesis(SPPS) support consists of small, polymeric resin beads functionalized with reactive group such as amine or hydroxyl groups, which link to systhesis peptide chain step by step.

Solid phase peptide synthesis(SPPS) resins is insoluble in all common solvents but swells well in most organic solvents. Better swelling degree is benefit for the reaction yields, but for short peptide easy to synthesis, lower swelling degree will be suitable and it will be good at saving solvent.

Solid phase peptide synthesis Resins are rich in variety, complete in specifications and stable in performance.

Typical Applications

  • Solid phase synthesis of Bivalirudin
  • Solid phase synthesis of Eptifibatide
  • Solid phase synthesis of Exenatide
  • Solid phase synthesis of Liraglutide
  • Solid phase synthesis of thymopentin
  • Solid phase synthesis of Thymalfasin
  • Solid phase synthesis of Buserelin
  • Solid phase synthesis of Goserelin
  • Solid phase synthesis of Octreotide
  • Solid phase synthesis of Calcitonin

Our Customized Service

We also have good experiences in research and develop the amine acid pre-loading peptide resins, and we have extended resin backbone to hydrophilic matrix, such as DEG series, TEG series, PEG series. Welcome to ask for Sunresin!

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Latest News

30 2022-09
Sunresin among the "Top 50 Listed Companies on the Growth Enterprise Market"

The list of "The 16th Listed Company Value Selection" of China was announced. Sunresin New Materials Co., Ltd. was selected into the "Top 50 Most Valuable Listed Companies on the Growth Enterprise Market" list. "China’s Listed Company Value Selection" is hosted by Securities Times and has been held for 16 consecutive years, as one of the most influential selections in the field of listed companies hosted by mainstream financial media in China.

22 2022-09
Sunresin’s 4000t/a Jintai salt lake lithium extraction project put into operation

On September 21, Jintai Lithium Industry’s Phase-Two 4000t/a lithium carbonate project undertaken by Sunresin started production. Up to now, Sunresin has completed an accumulated 7000t/a lithium carbonate for Jintai Lithium Industry.

26 2022-08
Sunresin Signs MOU with Anson Resources for Lithium Project in Utah

Sunresin is delighted to announce that a Memorandum of Understanding ("MoU") has been signed with Anson Resources Limited (ASX: ASN), an Australian-based exploration and development company for industrial minerals, on a long-term alliance for the Paradox lithium project in Utah. According to the MoU, Sunresin will provide equipment, consumables, innovations and technical support services to Anson for the development, design, construction, operation and optimization of Sunresin’s proprietary Direct Lithium Extraction (DLE) technology for the production of battery-grade lithium carbonate at the Paradox project in Utah, USA.

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